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Wisconsin Registry for Alzheimer's Prevention (WRAP)

Promise for the advancement in the early detection and prevention of AD is possible through the collaborative efforts of the WAI; the UW School of Medicine and Public Health Section of Geriatrics and Gerontology, the Department of Neurology, and the Wisconsin Comprehensive Memory Program; and the Madison VA Medical Center, Geriatrics Research, Education, and Clinical Center (GRECC). With support from the Northwestern Mutual and Helen Bader Foundations in Milwaukee, the WAI developed the Wisconsin Registry for Alzheimer’s Prevention (WRAP).

A cure for Alzheimer’s disease depends on people for inspiration
and participation and on research for realization

The WAI is currently recruiting 850 adult children of persons diagnosed with Alzheimer’s disease and 350 people whose parents did not have Alzheimer’s disease into WRAP. For information on joining WRAP, click here.

Participants in WRAP whose parent(s) have AD are being studied because of their increased risk of developing AD and because they are the ones most likely to benefit from advances in our understanding of it.

Participants in WRAP provide health, lifestyle, and genetic information and complete memory and cognitive testing every 4 years. It is hoped that participants will continue to participate in WRAP for 15 years, but are free to withdraw at any time.

If you would like to learn more about WRAP and possible participation, please contact Janet Rowley at the WAI.

Phone: 608-829-3306 or 1-800-417-4169
Email: jsrowley@wisc.edu

As part of WRAP, many participants choose to enroll in memory research studies conducted by the UW School of Medicine and Public Health, Wisconsin Comprehensive Memory Program that look at such things as the relationship between cholesterol-lowering medications and AD, and the use of functional magnetic imaging of the brain to detect signs of AD in early stages of the disease process. Click the link above for further information on studies at the Wisconsin Comprehensive Memory Program.

Future Plans

It is our hope that in the future a new longitudinal study will be available to WRAP participants looking at why persons at different levels of genetic risk proceed or do not proceed to develop the disease.

WRAP Findings to Date

ARTICLE: Middle-Aged Children of Persons with Alzheimer's Disease: APOE Genotypes and Cognitive Function in the Wisconsin Registry for Alzheimer's Prevention

Written by Mark Sager, MD, Bruce Hermann, PhD, and Asenath La Rue, PhD, Wisconsin Alzheimer's Institute

Published in the Journal of Geriatric Psychology and Neurology, Vol. 18, No. 4, December 2005. © Sage Publications
Older couple
The Urgency of Our Mission

In the U.S. approximately 5-10% of the population aged 65 and older has AD. In Wisconsin, this number is expected to increase by 58% from 103,000 to 163,000 persons over the next 25 years.

19 million Americans say someone in their family has the disease.

50% of persons with AD are undiagnosed and therefore, untreated.

Families delay seeking help for almost three years after the onset of cognitive symptoms.

50% of nursing home residents have AD or a related disorder.

Family and friends provide almost 75% of home care. Costs for at-home care average $12,500 each year with families paying almost the entire cost out-of-pocket.